Role of ?1 integrin in thrombocytopoiesis

Thrombocytopoiesis is a complex process beginning at the level of hematopoietic stem cells, which ultimately generate megakaryocytes, large marrow cells with distinctive morphology, and then, through terminal maturation, megakaryocytes shed thousands platelets into circulation. This controlled by intrinsic extrinsic factors. Emerging data indicate that an important control on late stages thrombopoiesis exerted integrins, family transmembrane receptors composed one ? ? subunit. One subunit expressed ?1 integrin, role in regulation platelet formation to be clarified. Here, we review recent indicating activation integrin outside-in inside-out signaling regulates interaction endosteal niche, triggers their while its inactivation galactosylation determines migration these perivascular where they complete maturation release bloodstream. Furthermore, mediates transforming growth factor (TGF-?), protein produced may act autocrine fashion halt affect composition surrounding extracellular matrix. These findings suggest could therapeutic target for inherited acquired disorders production.